A class of nonsteroidal anti-inflammatory drugs known as oxicams (NSAIDs) Oxicams are a class of nonsteroidal anti-inflammatory medicines (NSAIDs) with strong analgesic, antipyretic, and anti-inflammatory effects. Since their introduction in the 1980s, these drugs have proven indispensable for the treatment of a wide range of inflammatory ailments, from acute pain to arthritis. A unique characteristic of oxicams is their specificity in blocking the enzyme cyclooxygenase (COX), specifically COX-2. Oxicams effectively inhibit the synthesis of prostaglandins, which are important mediators of fever, pain, and inflammation, by specifically targeting this enzyme. They differ from earlier NSAIDs in that they do not inhibit both COX-1 and COX-2, which increases the likelihood of gastrointestinal adverse effects. Following the introduction of piroxicam, other members such as meloxicam, tenoxicam, and lornoxicam were also introduced. All of these medications have the oxicam ring, which is essential to their pharmacological action, and have similar chemical structures. One of the most regularly prescribed oxicams is meloxicam, which is often used to treat rheumatoid arthritis and osteoarthritis. Patients may find it more convenient to adhere to treatment regimens due to its once-daily dose. Conversely, tenoxicam has a longer half-life that enables less frequent dosage, which may be advantageous for some patients. Oxicams are effective, but they do have certain drawbacks. Similar to other NSAIDs, they may result in bleeding and ulcers in the gastrointestinal tract, especially if used excessively or for an extended period of time. Individuals who have experienced bleeding in the gastrointestinal tract or peptic ulcers should use oxicams cautiously and under a doctor's supervision. The possible effect of oxicams on renal function is a further worry, particularly with long-term use. These medications may cause sodium and water retention, which can worsen hypertension and produce edema by impairing renal blood flow. When utilizing oxicams, patients with pre-existing renal problems or those using diuretics should be closely watched. To sum up, oxicams are useful medications for treating pain and inflammation brought on by a variety of illnesses. Compared to previous NSAIDs, its targeted COX-2 inhibition offers a more favorable side effect profile, but clinicians still need to be on the lookout for potential renal and gastrointestinal problems. To guarantee the best results for patients, the advantages and disadvantages of prescribing oxicams should be thoroughly considered, just like with other medication.