Methylindoles are a type of chemical molecule that has both an indole ring and a methyl group. The indole ring is a bicyclic structure composed of a benzene ring joined with a pyrrole ring. The addition of a methyl group to this indole structure confers distinct chemical and biological features. 5-MeO-DMT, a potent hallucinogenic chemical present in a variety of plant species and used in shamanic rituals, is a well-known example of methylindole. It is known to cause strong spiritual experiences and altered states of consciousness. The methyl group of 5-MeO-DMT is critical to its pharmacological function, as it influences its interaction with serotonin receptors in the brain. The addition of a methyl group in indole compounds can alter their aromatic and electrical characteristics. Methylindoles can be more stable and have different reactivity than their non-methylated counterparts. This alteration can alter the compound's biological function, making methylindoles valuable in medicinal chemistry and medication development. Some methylindoles found in natural goods are derived from marine organisms and have unique biological properties. For example, several sea sponges create methylindole alkaloids that are antifungal and cytotoxic. These chemicals have piqued the interest of researchers looking for new sources of bioactive molecules for medicinal purposes. The synthesis of methylindoles has piqued organic chemists' interest. Several ways have been discovered to insert the methyl group into precise places on the indole ring. These synthetic techniques enable the synthesis of a wide range of methylindole derivatives with various substituents, allowing for the investigation of structure-activity connections. In summary, methylindoles are a versatile class of chemicals with numerous uses in pharmacology, medicinal chemistry, and natural product research. Their unusual structure, impacted by the inclusion of a methyl group into the indole ring, contributes to their specific chemical and biological capabilities, making them an intriguing topic of study within the larger field of organic chemistry.