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Meglitinides are a class of oral hypoglycemic agents used in the management of type 2 diabetes mellitus. These drugs work by stimulating insulin secretion from the beta cells of the pancreas, promoting glucose uptake by peripheral tissues and lowering blood glucose levels. One of the key features of meglitinides is their rapid onset of action and short duration, making them particularly suitable for controlling postprandial (after meals) glucose spikes. Repaglinide and nateglinide are two common meglitinides prescribed for diabetes management. Unlike sulfonylureas, another class of insulin secretagogues, meglitinides have a quicker onset and a shorter duration of action, reducing the risk of prolonged hypoglycemia. Meglitinides are typically taken before meals to coincide with the anticipated increase in blood glucose levels following food consumption. Their mechanism of action involves binding to the ATP-sensitive potassium channels on pancreatic beta cells, leading to insulin release in response to elevated blood glucose. While meglitinides offer advantages in terms of flexibility and reduced risk of hypoglycemia, they may not be suitable for all individuals and are often prescribed in combination with other diabetes medications. As with any medication, proper dosing and monitoring are crucial to optimizing glycemic control and minimizing potential side effects.