Within the larger category of hallucinogens, there is a class of psychoactive chemicals known as ligergamides. These substances are distinguished by their structural similarity to lysergic acid, a substance that is present in many fungus and some plant seeds naturally. The most well-known lysergamide is lysergic acid diethylamide, or LSD. It is a strong hallucinogen that was popularized during the counterculture of the 1960s. A bicyclic indole ring system makes up the fundamental structure of lysergamides, and a variety of derivatives and analogs have unique effects on the mind and senses of humans. A prevalent theme in many naturally occurring chemicals, the indole ring is what gives lysergamides their hallucinogenic qualities. The classic lysergamide, LSD, is well-known for its potent hallucinogenic effects, which can change perception, mood, and mental processes. It mainly affects the brain's serotonin receptors, specifically the 5-HT2A receptor, which alters cognitive functions and sensory perception. A heightened awareness of emotions, altered sense of time, and vivid visual hallucinations are common complaints from users. Although the most well-known lysergamide is LSD, this class of chemicals contains other substances that have also been investigated for their psychotropic properties. The lysergamides ALD-52 (1-Acetyl-LSD), ETH-LAD (6-ethyl-6-nor-lysergic acid diethylamide), and AL-LAD (6-allyl-6-nor-lysergic acid diethylamide) have drawn interest from the scientific community and psychedelic circles. The study of lysergamides has expanded to include possible medicinal uses. Research has examined the impact of these substances on psychological disorders as depression, anxiety, and PTSD. However, there hasn't been much research done in this field because of legal and regulatory restrictions. It is important to remember that using lysergamides recreationally has hazards, such as erratic behavior, difficult experiences (sometimes referred to as "bad trips"), and possibly long-term psychological repercussions. Different legal countries have different limits; many lysergamides are considered prohibited substances. In conclusion, lysergamides are an intriguing class of psychoactive substances with a varied range of effects on human consciousness and a rich historical background. Scientific investigation and discussion have not stopped regarding their therapeutic potential or their mechanisms of action.