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The class of psychoactive chemicals known as arylcyclohexylamines is well-known for its distinctive effects on human behavior and the brain. Because of their varied pharmacological characteristics, these compounds—which have an aryl group connected to a cyclohexylamine backbone—have become more and more well-liked in the fields of scientific research and recreational drug usage. We take a quick look at arylcyclohexylamines in this section. Phencyclidine (PCP), one of the most well-known arylcyclohexylamines, was first created in the 1950s as a dissociative anesthetic. But PCP's major adverse effects—such as delirium, hallucinations, and erratic behavior—led to its withdrawal from medical use. Nevertheless, it made its way into recreational drug markets, where its hallucinogenic properties led to its notoriety. Ketamine is another well-known member of this class that has grown in acceptance in both non-medical and medicinal contexts. Ketamine is useful for anesthesia because of its dissociative qualities, particularly in emergency conditions. Furthermore, because of its antidepressant properties, it has drawn interest as a possible treatment for major depressive disorder and other mood disorders. A more recent member of the arylcyclohexylamine family is methylxetamine (MXE). MXE, which was created as a ketamine mimic, became well-known for recreational drug use in the early 2010s. Its strong dissociation qualities and extended half-life were highly regarded, earning it the designation of "research chemical." However, MXE has been subject to regulatory restrictions in many countries because of its uncontrolled nature and the paucity of data on its long-term consequences. A other component with comparable dissociative effects is 3-MeO-PCP, a derivative of PCP. Those looking for new psychoactive experiences have taken an interest in it. But 3-MeO-PCP's strength and erratic effects, like those of many other drugs in this class, raise questions regarding its safety. The main way that arylcyclohexylamines work is by inhibiting NMDA receptors in the brain, which can cause hallucinations, altered perception, and separation from the self. Some people find these substances fascinating, but they can also be harmful due to their unique combination of alienation from reality and sensory distortions. To sum up, arylcyclohexylamines are an intriguing and varied class of psychotropic drugs with a convoluted past. These substances continue to pique the interest of academics, doctors, and others interested in altered states of consciousness, from the recreational use of PCP and its derivatives to the medical applications of ketamine. Nonetheless, their potential for harm underscores how crucial it is to comprehend their effects and hazards, particularly in uncontrolled situations.