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Antiplatelet Drugs

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A class of pharmaceuticals known as antiplatelet drugs works by preventing platelets, which are essential blood components involved in the development of clots, from aggregating. Cardiovascular disorders, especially those associated with arterial thrombosis, are frequently treated and prevented with these drugs. Below is a summary of several popular antiplatelet medications: Acetylsalicylic acid, or aspirin, is one of the most well-known and traditional antiplatelet medications. It functions by permanently blocking the cyclooxygenase (COX) enzyme, which is necessary for the synthesis of the powerful platelet aggregator thromboxane A2.Aspirin decreases platelet aggregation and blood clot formation by blocking thromboxane A2.In individuals with a history of cardiovascular disease, it is frequently recommended to prevent heart attacks and strokes as well as their recurrence. Clindamycin (Plavix):Another popular antiplatelet drug is clopidogrel. It belongs to the thienopyridine class and acts on platelets by permanently blocking the P2Y12 receptor, which is necessary for platelet activation and aggregation. For patients with acute coronary syndrome (ACS), following coronary artery stenting, and in those with a history of stroke or peripheral artery disease, clopidogrel is frequently given in conjunction with aspirin. Brilinta, or Ticagrelor: A more recent antiplatelet drug, ticagrelor is a member of the P2Y12 receptor antagonist class. Ticlogrelor is a reversible P2Y12 receptor inhibitor, in contrast to clopidogrel. When compared to clopidogrel, it has a quicker onset of action and stronger antiplatelet effects. When treating patients with ACS, especially those undergoing percutaneous coronary intervention (PCI), ticagrelor is frequently utilized in place of clopidogrel. Prasugrel Another thienopyridine antiplatelet medication is prasugrel. It functions by permanently blocking the P2Y12 receptor on platelets, just like clopidogrel. Prasugrel is especially helpful for individuals receiving PCI for ACS since it has a stronger and faster antiplatelet effect than clopidogrel. However, compared to clopidogrel, it is linked to a higher risk of bleeding and is typically saved for individuals who are at a high risk of thrombotic events. To sum up, antiplatelet medications are essential for keeping patients with cardiovascular illnesses from experiencing thrombotic episodes. By obstructing receptors or enzymes involved in platelet activation, for example, they prevent platelet aggregation. These drugs are recommended to balance the risk of bleeding and thrombosis, depending on the particular clinical situation.