Acetoacetate esters, sometimes referred to as ketone esters, are an intriguing family of substances that have attracted a lot of attention recently because of their potential advantages for both health and performance. These substances are synthesized versions of acetoacetate, a ketone body produced by the liver during fasting, low-carbohydrate diets, and strenuous exercise. Because acetoacetate esters can quickly increase blood ketone levels, they offer a different energy source for the body and brain. Acetoacetate esters' connection to ketosis, a metabolic state defined by an increase in the production and consumption of ketones like acetoacetate, is one of the main reasons for their rising popularity. Ketosis has been associated to a number of potential health advantages, such as better control of weight, improved cognitive function, and higher physical endurance. Acetoacetate esters are appealing to athletes, biohackers, and those looking to improve their performance and well-being because they provide a convenient option to induce ketosis without imposing stringent dietary restrictions. Acetoacetate esters have aroused interest in the field of neurology and diseases associated with neurodegenerative disorders in addition to their potential advantages for health and performance. Acetoacetate is one of the ketone compounds that has demonstrated potential as a substitute fuel source for the brain. This finding may have therapeutic implications for diseases including epilepsy, Alzheimer's disease, and Parkinson's disease. There is now active research on the neuroprotective and cognitively boosting properties of acetoacetate esters, and it shows promise for treating these difficult medical disorders. The use of acetoacetate esters should be done with caution and under medical supervision, especially for people with underlying health concerns or those who are new to ketogenic diets, despite the fact that they have tremendous potential. To completely comprehend their long-term impacts and safety profiles, more research is also required. Nevertheless, research into acetoacetate esters is a fascinating new area in the study of nutrition, physiology, and medicine, with intriguing potential for enhancing human performance.