The advantages of gels and microemulsions are combined in microemulsion-based gels, a unique drug delivery technology that improves the solubility, ... The advantages of gels and microemulsions are combined in microemulsion-based gels, a unique drug delivery technology that improves the solubility, stability, and bioavailability of active pharmaceutical ingredients (APIs). Because of this system's special qualities and wide range of uses, the pharmaceutical and cosmetic sectors have shown a great deal of interest. Microemulsions are systems consisting of water, oil, surfactant, and co-surfactant that are isotropic and thermodynamically stable. When these elements are combined in the right amounts, they form on their own. The dispersed phase's nanoscale droplets, which are usually between 10 and 100 nm in size, form a transparent or translucent system with low interfacial tension and a high solubilizing capacity in the continuous phase. The liquid microemulsion is combined with a gelling agent, such as carbopol, xanthan gum, or hydroxypropyl methylcellulose (HPMC), to form a microemulsion-based gel. By combining these two ingredients, the liquid microemulsion becomes a semi-solid gel that retains its advantages and improves handling and application capabilities. Improved Solubility and Bioavailability: By increasing the surface area, the nanoscale droplets help make poorly water-soluble medications more soluble and more bioavailable. Controlled Release: The gel matrix has the ability to adjust the drug's rate of release, resulting in a steady and regulated dosage. Gels based on microemulsions find wide uses in the cosmetics and pharmaceutical industries. They are applied topically to administer medications in dermatology, allowing for targeted therapy with less systemic absorption. They are also used in transdermal delivery systems, which use the skin to administer drugs systemically. These gels are used in cosmetics to provide active substances such as vitamins, antioxidants, and anti-aging agents, which provide longer-lasting effects and improved penetration. A noteworthy development in drug delivery technology, microemulsion-based gels present a viable strategy for boosting the stability and effectiveness of a range of therapeutic medicines. Their special qualities and adaptability make them an important tool for creating cutting-edge medical and cosmetic goods. Further developments in formulation and application are anticipated as research advances, hence increasing the delivery system's potential.