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Antiplatelet Drugs

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Antiplatelet medications lower the risk of heart attack, stroke, and other cardiovascular events by preventing blood clots from forming. They function by preventing platelets—blood cells that are in charge of clotting—from activating. The following are a few popular antiplatelet medications:Acetylsalicylic acid, or aspirin:one of the most popular and traditional antiplatelet medications. functions by permanently blocking the cyclooxygenase (COX) enzyme, which lowers the synthesis of thromboxane A2, a strong platelet aggregator. used in a range of dosages, ranging from 81 mg as a low-dose preventive to higher doses for acute occurrences. frequently utilized in individuals who have had stent placement, peripheral vascular disease, and coronary artery disease. Clindamycin (Plavix): A thienopyridine derivative used as an oral antiplatelet drug. prevents ADP-induced platelet aggregation by blocking the P2Y12 adenosine diphosphate (ADP) receptor on platelet cell membranes. frequently given in addition to aspirin to patients suffering with peripheral artery disease, recent myocardial infarction (MI), stroke, or acute coronary syndrome (ACS). takes a few days to really take action because the liver needs to be metabolically activated. Brilinta, or Ticagrelor: An additional oral antiplatelet drug from the P2Y12 receptor inhibitor class. prevents platelet activation and aggregation mediated by ADP by acting reversibly on the P2Y12 receptor. has a quicker start of action than clopidogrel. often used in conjunction with aspirin in patients diagnosed with ACS. Prasugrel with efficacy: An additional oral P2Y12 receptor inhibitor that works more steadily and potently than clopidogrel. Additionally utilized in individuals with ACS undergoing PCI (percutaneous coronary intervention). Compared to clopidogrel, can increase the risk of bleeding, particularly in patients with a history of stroke or transient ischemic attack. Dipyridamole: accessible as injectable and oral versions. increases the amount of cyclic adenosine monophosphate (cAMP) in platelets, which prevents platelets from aggregating and inhibits platelet activity. frequently used with aspirin to prevent stroke in those who have experienced transient ischemic episodes (TIAs). These medications, which are frequently customized based on the patient's unique risk factors and medical history, are essential in the treatment of a variety of cardiovascular diseases. They do, however, also come with a risk of bleeding, which needs to be well watched, particularly if taken in addition to other blood thinners.