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Anti-angiogenic medications represent a fresh approach to cancer treatment and beyond. Angiogenesis, or the formation of new blood vessels from pre-existing ones, is essential for a variety of physiological processes, including wound healing and embryonic development. However, if left unchecked, it contributes considerably to the evolution of diseases such as cancer, diabetic retinopathy, and rheumatoid arthritis. The basic goal of anti-angiogenic therapy is to prevent the creation of new blood vessels, so cutting off the delivery of nutrients and oxygen to sick areas. These therapies try to limit or halt the aberrant growth of blood vessels by targeting the signaling pathways and molecules involved in angiogenesis, hence preventing cancer progression and metastasis. One of the major tactics used in anti-angiogenic therapy is to inhibit the function of vascular endothelial growth factor (VEGF), a protein that promotes the creation of blood vessels. Bevacizumab and aflibercept are monoclonal antibodies that specifically target VEGF, preventing it from attaching to receptors on blood vessel cells and interfering with the angiogenic process. Furthermore, small molecule inhibitors like sunitinib and sorafenib interfere with the signaling pathways involved in blood vessel creation, resulting in anti-angiogenic effects. These medicines have demonstrated encouraging effects in malignancies such as colorectal, lung, kidney, and breast.Combining anti-angiogenic medications with traditional treatments such as chemotherapy or radiation therapy has been shown to have synergistic benefits, improving overall therapeutic outcomes. Furthermore, their generally mild side effect profiles have made them useful in clinical practice. Despite these advances, anti-angiogenic therapy remains challenging. Resistance to treatment can develop over time, causing disease progression. Furthermore, some people may develop side effects such as hypertension, bleeding, or poor wound healing. Ongoing research tries to solve these challenges by finding new targets, investigating combination therapy, and improving drug delivery systems. Personalized medicine techniques, which personalize treatments based on individual genetic profiles and tumor features, show promise for improving the efficiency of anti-angiogenic medications while limiting side effects. To summarize, anti-angiogenic treatments are a game-changing technique with enormous potential for treating a variety of disorders, including cancer. Continued research and improvement of these treatments is critical to realizing their full therapeutic potential and improving patient outcomes.